Having spent the weekend in Philadelphia, I was reminded of this clip I had heard first and later seen of Bill Burr, a Boston area comic. He was in Philly with Opie and Anthony and a bunch of other comedians on tour. Dom Irrerra, a Philly native and stand-up comedian, was before him on the show. The no-neck crowd booed Irrerra until he left the stage without doing his act.
Burr came out on stage angry that they had booed him and then the crowd turned on him.
What happened next was awesome. Burr essentially stopped doing material and just turned on the hostile crowd and their awful city for 10 minutes. Thank you internets for this. Oh, and super NSFW.